Korean J Obstet Gynecol.  2000 Apr;43(4):747-750.

Control of Postpartum Bleeding by Rectal Misoprostols: A Report of 2 Cases

• Han ST
• Jung SH
• La YH
• Seo LL
• Jung WC
• Lee SW
• Cho Y
• Ro ES

Abstract

Obstetrical hemorrhage is one of the deadly triad, along with hypertensive disorder in pregnancy and infection. Postpartum hemorrhage is the major cause of obstetrical hemorrhage. Uterine atony is the most common cause of postpartum hemorrhage, and resulted from poor uterine contraction after delivery of the fetus and placenta. Initial management to control postpartum uterine atonic bleeding is based on the use of uterotonics such as well known oxytocin and ergot preparations together with uterine massage. Prostaglandin E2 analogue, sulprostone can be used next when these agents are failed to produce uterine contraction. The woman unresponsive to non-surgical managements requires surgical interventions including emergency hysterectomy. Recently prostaglandin E1 analogue, misoprostol, has been known to elicit potent uterine contraction and cervical ripening after oral, vaginal or rectal administration. We have experienced two cases of postpartum uterine atonic bleedings which were unresponsive to oxytocin, ergot, or prostaglandin E2, but were successfully controlled by rectal administration of misoprostols.

Keyword

Postpartum hemorrhage; Uterine atony; Misoprostol

MeSH Terms

Administration, Rectal
Alprostadil
Cervical Ripening
Dinoprostone
Emergencies
Female
Fetus
Hemorrhage*
Humans
Hysterectomy
Massage
Misoprostol*
Oxytocin
Placenta
Postpartum Hemorrhage
Postpartum Period*
Pregnancy
Uterine Contraction
Uterine Inertia
Alprostadil
Dinoprostone
Misoprostol
Oxytocin