The Clinical Evaluation of Triple Combined Test [ Cytology, HPV DNA Test, Cervicography] for Uterine Cervical Cancer

Rho, H G; Cho, S M; Han, S J

Abstract

Objective
The purpose of this study was to compare cervical cytology[Pap smear], HPV DNA test, cervicography, first double combined test of cervical cytology and HPV DNA test, second double combined test of cervical cytology and cervicography and triple combined test of cervical cytology, HPV DNA test and cervicography. Study design; This study included 261 patients who visited for cervical cancer screening at the department of Obstetrics and Gynecology, Chosun university hospital from Dec. 1, 1995 to Nov. 30, 1996. All women simultaneously underwent cervical cytology, HPV DNA test and cervicography for cervical cancer screening and colposcopically directed biopsy for diagnostic evaluation. RESULTS: The triple combined test[cervical cytology + cervicography + HPV DNA test; 100%] was most sensitive among the cervical screening tests[100%]. Second double combined test[cervical cytology + cervicography; 98.1%] was more sensitive than first double combined test[cervical cytology + HPV DNA test; 92.3%]. But cervical cytology was most specific[93.5%] and showed the highest positive predictive value[77.8%]. CONCLUSIONS: The sensitivity of cervical cytology was markedly improved by combination with HPV DNA test and cervicography. So the triple combined test which improve high false negativity of cervical cytology may be a new effective tool as a cervical cancer screening test, if the effectiveness is confirmed by mass screening study.