Effect of Hydrosalpinx on IVF Outcome in Controlled Ovarian Hyperstimulation Cycles and CryopreservedEmbryo Transfer Cycles

Song, In Ok; Yeon, Hye Jung; Lee, Jong Pyo; Yoo, Keun Jai; Kim, Kye Hyun; Paik, Eun Chan; Koong, Mi Kyoung; Son, Il Pyo; Jun, Jong Young; Kang, Inn Soo

Abstract

This study was performed to determine the effect of hydrosalpinx on the outcome with in vitro fertilization and embryo transfer(IVF-ET). Hydrosalpingeal fluid may leak into theuterine cavity during or after ovarian hyperstimulation and can cause deletorious effect onembryo or implantation. Herein, we reported the effect of hydrosalpinx on the cycle outcomeof IVF in controlled ovarian hyperstimulation cycles and cryopreserved-thawed embryotransfer cycles.In controlled ovarian hyperstimulation cycles, comparisons were made between 59 IVFcycles of 54 patients having tubal disease without hydrosalpinx(control group) and 36 IVFcycles of 35 patients carrying hydrosalpinx(hydrosalpinx group). Both clinical pregnancyand implantation rates were significantly lower in hydrosalpinx group(25.4 versus 8.3%,and 11.6 versus 2.0% respectively). Four ectopic pregnancies were noted in hydrosalpinxgroup compared to one in the control group.In cryopreserved-thawed embryo transfer cycles, comparisons were made between 27IVF cycles of 25 patients having tubal disease without hydrosalpinx(control group) and 13IVF cycles of 13 patients carrying hydrosalpinx(hydrosalpinx group). There was a tendencyof decreased pregnancy and implantation rates in hydrosalpinx group compared to the control(37.0 versus 15.4%, and 9.9% versus 4.0% respectively). One ectopic pregnancy was notedin the hydrosalpinx group compared to none in the control group.These data indicate that the presence of hydrosalpinx may negatively affect IVF outcome.We suggest that patients presenting with hydrosalpinx should consider surgical correctionto optimize their outcome with IVF procedure.