Korean J Obstet Gynecol.  1997 Apr;40(4):740-746.

Intravenous Immunoglobulin Treatment in Women with Unexplained Recurrent Spontaneous Abortion

• Shin MS
• Kim NY
• Kim CH
• Kang BM
• Chang YS
• Mok JE

Abstract

This study was undertaken to verify a specific effect of intravenous immunoglobulin treatment on the outcome of pregnancy in the patients with a history of unexplained recurrent spontaneous abortion. Five patients with a history of unexplained recurrent spontaneous abortion were treated with intravenous immunoglobulin during their following pregnancy, as soon as pregnancy was confirmed. When pregnancy was confirmed, women were started with 10 gm of immunoglobulin intravenously which was repeated every 2 weeks and four to six times. One of them experienced termination of pregnancy due to blighted ovum syndrome at 9th weeks of gestation and four patients delivered live births at term. Two of them had experienced cesarean section because of breech presentation and placenta previa respectively, rest of them delivered vaginally without problem. There were no adverse reaction in the study patients. These results imply that intravenous immunoglobulin could be effective on the patients with a history of unexplained recurrent spontaneous abortion, and could be applied to them as an alternative method of allogenic leukocyte transfusion.

Keyword

Unexplained recurrent spontaneous abortion; Intravenous immunoglobulin

MeSH Terms

Abortion, Spontaneous*
Breech Presentation
Cesarean Section
Female
Humans
Immunoglobulins*
Leukocyte Transfusion
Live Birth
Ovum
Placenta Previa
Pregnancy
Immunoglobulins