Korean J Med.
2010 Apr;78(4):485-489.
Regression of colon polyposis after aspirin medication
- Affiliations
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- 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. swjeon@knu.ac.kr
Abstract
- There is considerable evidence that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of colorectal neoplasia. Unlike cyclooxygenase-1 (COX-1), which is constitutively expressed in the colon, COX-2 is overexpressed in colorectal cancers and adenomas in human. Aspirin inhibits the generation of prostaglandins by inhibiting both COX-1 and COX-2, which initiate prostaglandin synthesis. The chemopreventive effect of aspirin against the development of colorectal adenomas has been widely investigated. However, there is no agreement on the effect of aspirin on existing adenomas. We describe a case of colon polyposis that disappeared after aspirin medication.
