Korean J Med.  2011 May;80(5):553-561.

Clinical Differences According to Genotype in Acute Viral Hepatitis A in Daejeon, Korea

Affiliations
  • 1Division of Gastroenterology, Department of Internal Medicine, Eulji University College of Medicine, Daejeon, Korea. 20040544@eulji.ac.kr
  • 2Department of Preventive Medicine, Eulji University Hospital, Eulji University College of Medicine, Daejeon, Korea.

Abstract

BACKGROUND/AIMS
Acute viral hepatitis A is a major health problem in Korea and the influx of genotype IIIA is thought to be one reason. We examined the differences in the clinical characteristics and laboratory findings of genotypes IA and IIIA in Daejeon.
METHODS
From November 2009 to June 2010, 81 patients positive for IgM anti-HAV were enrolled prospectively. The hepatitis A was genotyped using real-time polymerase chain reaction. The clinical characteristics and laboratory results were compared on the basis of genotype.
RESULTS
The mean patient age was 32.6 +/- 7.4 years. The mean hospitalization was 7.7 +/- 2.4 days. The patient occupation varied. Clinically, vomiting and diarrhea were relatively more prevalent in genotype IIIA than in IA. Abdominal pain and skin spots were relatively more prevalent in genotype IA than in IIIA. The hemoglobin, peak aspartate aminotransferase (AST) level, and C-reactive protein were statistically higher in genotype IIIA than in IA. The distributions of the peak AST, alanine aminotransferase (ALT) and total bilirubin values tended to be perched in genotype IIIA than in IA. The international normalized ratio (INR) tended to be slightly prolonged in genotype IIIA than in IA.
CONCLUSIONS
Recently, genotype IIIA of acute viral hepatitis A has become prevalent in Daejeon. Hepatitis A genotype IIIA probably causes worse laboratory abnormalities than genotype IA.

Keyword

Hepatitis A; Prevalence; Genotype

MeSH Terms

Abdominal Pain
Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
C-Reactive Protein
Diarrhea
Genotype
Hemoglobins
Hepatitis
Hepatitis A
Hepatitis A Antibodies
Hospitalization
Humans
Immunoglobulin M
International Normalized Ratio
Korea
Occupations
Perches
Prevalence
Prospective Studies
Real-Time Polymerase Chain Reaction
Skin
Vomiting
Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
C-Reactive Protein
Hemoglobins
Hepatitis A Antibodies
Immunoglobulin M
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