Korean J Med.  2009 Jun;76(6):692-700.

Relationship between the low-density lipoprotein cholesterol level and clinical outcome after percutaneous coronary intervention in patients with acute myocardial infarction

• Cho KH
• Jeong MH
• Park KH
• Lee MG
• Ko JS
• Lee SE
• Kang WY
• Kim SH
• Sim DS
• Yoon NS
• Youn HJ
• Hong YJ
• Park HW
• Kim JH
• Ahn Y
• Cho JG
• Park JC
• Kang JC

Abstract

BACKGROUND/AIMS: This study examined the relationship between the low-density lipoprotein cholesterol (LDL-C) level and clinical outcome after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).
METHODS
Between January 2006 and December 2007, 867 patients (age, 62.6+/-12.5 years; males, 71%) undergoing a 1-year follow- up after PCI for AMI were divided into five groups according to the LDL-C level: <70, 70-100, 100-130, 130-160, and > or =160 mg/dL.
RESULTS
Smoking (63%), hypertension (46%), and diabetes mellitus (28%) were common risk factors. The history of ischemic heart disease decreased as the LDL-C level increased (p=0.036). Patients with lower LDL-C levels had lower creatinine clearance and higher high-sensitivity C-reactive protein (hsCRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. The rate of in-hospital complications after PCI declined with increases in the LDL-C level, except in patients with LDL-C >160 mg/dL (linear p=0.010). There was no correlation between the LDL-C level and the 30-day or 1-year clinical outcome after PCI. After multivariate adjustment, independent predictors of the 1-year mortality after PCI were left ventricular ejection fraction, hsCRP, age, and creatinine clearance.
CONCLUSIONS
Higher LDL-C levels were related to fewer in-hospital complications, but there was no correlation between the LDL-C level and long-term clinical outcome after PCI in Korean patients with AMI.

Keyword

Myocardial infarction; Low-density lipoprotein cholesterol; Percutaneous coronary intervention

MeSH Terms

C-Reactive Protein
Cholesterol
Creatinine
Diabetes Mellitus
Humans
Hypertension
Lipoproteins
Male
Myocardial Infarction
Myocardial Ischemia
Percutaneous Coronary Intervention
Risk Factors
Smoke
Smoking
Stroke Volume
C-Reactive Protein
Cholesterol
Creatinine
Lipoproteins
Smoke