Korean J Med.
2008 Nov;75(5):592-596.
A case of rifampicin-induced interstitial pneumonitis
- Affiliations
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- 1Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea. jbh@gnah.co.kr
- 2Department of Radiology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea.
- 3Department of Pathology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea.
Abstract
- Rifampicin is a powerful agent for the treatment of pulmonary tuberculosis. However, it may induce several adverse effects, including rare cases of lung toxicity. Here, we report a case of rifampicin-induced interstitial pneumonitis. A 57-year-old woman diagnosed with cerebellar tuberculoma developed progressive dyspnea after the 5th day of anti-tuberculosis medication. Chest X-ray revealed newly developed ground glass opacities on both lower lung fields. Drug-induced pneumonitis was suspected and all anti-tuberculosis medications were halted. Transbronchial lung biopsy was consistent with desquamative interstitial pneumonitis. After clinical improvement, a rechallenge test with each anti-tuberculosis medication was attempted. No primary anti-tuberculosis drug except rifampicin triggered recurrence of symptoms, supporting a diagnosis of rifampicin-induced interstitial pneumonitis. Clinicians should be aware of this rare, but serious, side effect of rifampicin treatment.
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