Korean J Neurogastroenterol Motil.
2006 Jun;12(1):35-40.
Clinical Significance of Anti-tissue Transglutaminase as a Screening Method for Celiac Disease in a Korean Population
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. choim@catholic.ac.kr
- 2Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
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BACKGROUND/AIMS: Screening for celiac disease is recommended as part of the evaluation for irritable bowel syndrome in the Western countries due to the similarities in symptoms in the two diseases. The aim of this study was to investigate whether screening for celiac disease would be important in patients with functional gastrointestinal (GI) disorders in Korea.
METHODS
A total of 694 patients, who visited the GI clinic, were enrolled consecutively. Screening was performed by human recombinant anti-tissue transglutaminase (anti-tTG) IgA ELISA assay.
RESULTS
128 patients with functional GI disorders, who met the Rome II criteria, and 566 patients with organic GI disorders were subjected to this evaluation. Anti-tTG was positive in six patients (0.86%). None of the six patients met the diagnostic criteria for celiac disease, and the antibody positive results were regarded as false positive results. The final diagnoses for these six patients were: functional dyspepsia, Crohn's disease, esophageal ulcer, hepatocellular carcinoma, infectious colitis and cholecystitis One patient fulfilled the diagnostic criteria of celiac disease; however, the antibody test was negative in this patient. The specificity of anti-tTG was 99.1%. The antibody tests for all patients with functional colonic disorders were negative.
CONCLUSIONS
Screening for celiac disease did not add any benefit to the evaluation of Korean patients with the functional GI disorders.
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