Korean J Nephrol.  2004 Nov;23(6):1009-1014.

A Case of Carcinoid Tumor in a Patient with Focal Segmental Glomerulosclerosis

• Lee HK
• Lee YM
• Na KR
• Lee KW
• Jeong HY
• Suh KS
• Shin YT

Abstract

A renal lesion of neoplasm-related nephrotic syndrome usually presents as membranous nephropathy. Neoplasm-related nephrotic syndrome exhibiting focal segmental glomerulosclerosis (FSGS) has been reported mainly in patients with hematological malignancies. But reports of an association between FSGS and neoplasm are extremely rare. We report a 66-year-old woman with FSGS who presented with nephrotic syndrome and was subsequently found to have carcinoid tumors in the duodenum, confirmed by tissue biopsy. After resection of carcinoid tumor, the patient received initial treatment with oral prednisolone for 2 months but her nephrotic syndrome persisted. The patient was then treated with oral cyclophosphamide. One month later, she was in complete remission of nephrotic syndrome as indicated by a normal serum albumin and no proteinuria. This case may be a coincidence or the lesions may be linked with each other but since little is known about the pathogenesis of FSGS and neoplasm, it is difficult to speculate on a pathogenetic link between these two lesions. We report a case of FSGS with nephrotic syndrome in a patient with carcinoid tumor.

Keyword

Neoplasm-related nephrotic syndrome; Focal segmental glomerulosclerosis; Carcinoid tumor

MeSH Terms

Aged
Biopsy
Carcinoid Tumor*
Cyclophosphamide
Duodenum
Female
Glomerulonephritis, Membranous
Glomerulosclerosis, Focal Segmental*
Hematologic Neoplasms
Humans
Nephrotic Syndrome
Prednisolone
Proteinuria
Serum Albumin
Cyclophosphamide
Prednisolone
Serum Albumin