Korean J Nephrol.
2002 Jan;21(1):178-184.
A Case of Glomerulonephritis Associated with POEMS Syndrome
- Affiliations
-
- 1Department of Internal Medicine, Collage of Medicine, Dankook University, Cheonan, Korea.
- 2Department of Clinical Pathology, Collage of Medicine, Dankook University, Cheonan, Korea.
- 3Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- A POEMS syndrome(polyneuropathy, organomegaly, endocrinopathy, monoclonal M protein, and skin lesion) is a rare multisystem disease of unknown cause with varying clinical manifestations. POEMS- associated renal disease is also a rare condition. We experienced a 42-year-old male who had been suffered from generalized edema, low extremity weakness and pain. He also had a significant hematuria, proteinuria, azotemia, hepatospenomegaly, intraperitoneal lymph node enlargement, hypothyroidism, IgA lamda type monoclonal gammopathy, specific skin change and ascites. In renal biopsy, membranoproliferative features with enlarged glomeruli, mesangial proliferation, capillary wall thickening and paucity of immune deposit was noted. We suppose that renal insufficiency could come from POEMS syndrome. His symptoms such as low extremity pain, azotemia and generalized edema were improved by hemodialysis and use of prednisolone. At present, he is under the treatment of prednisolone and melphalan.
MeSH Terms
-
Adult
Ascites
Azotemia
Biopsy
Capillaries
Edema
Extremities
Glomerulonephritis*
Glomerulonephritis, Membranoproliferative
Hematuria
Humans
Hypothyroidism
Immunoglobulin A
Lymph Nodes
Male
Melphalan
Paraproteinemias
POEMS Syndrome*
Prednisolone
Proteinuria
Renal Dialysis
Renal Insufficiency
Skin
Immunoglobulin A
Melphalan
Prednisolone
