Korean J Nephrol.  2010 Jul;29(4):494-500.

One Case of Chronic Renal Failure and Another Case of Membraneous Glomerulonephritis Complicated by Acute A Viral Hepatitis

• Song IG
• Kang MG
• Na WT
• Kim ST
• Park MI
• Yun SH
• Yun SR

Abstract

Acute A viral hepatitis is a mild, self-limiting disease of liver and acute renal failure (ARF) is a rare complication. We report two cases of chronic renal failure (CRF) in nonfulminant acute A viral hepatitis and ARF. A 40-year-old man was admitted with ARF and acute A viral hepatitis, and underwent temporary hemodialysis therapy. The renal biopsy showed acute tubular necrosis with tubulointerstitial nephritis. At 13 months after discharge serum creatinine was 1.33 mg/dL and protein-creatinine ratio of spot urine was 0.47 (mg/mg Cr). The second case was a 28-year-old man and was managed conservatively. At discharge the serum creatinine was 3.14 mg/dL and the urinalysis showed hematuria, and protein-creatinine ratio 0.56 (mg/mg Cr). Thirty-nine months after discharge, the creatinine was 1.23 mg/dL, the urinalysis showed persistent nephritis findings and the protein-creatinine ratio 1.28. Kidney biopsy revealed the membranous glomerulopathy with mild tubulointerstitial nephritis, and all of findings suggested the systemic disease-associated secondary glomerulopathy. To our knowledge our case is the first one of chronic glomerulapathy that is confirmed by kidney biopsy.

Keyword

Acute renal failure; Chronic renal failure; Membranous glomerulopathy; A viral hepatitis

MeSH Terms

Acute Kidney Injury
Adult
Biopsy
Creatinine
Glomerulonephritis
Glomerulonephritis, Membranous
Hematuria
Hepatitis
Humans
Kidney
Kidney Failure, Chronic
Liver
Necrosis
Nephritis
Nephritis, Interstitial
Renal Dialysis
Urinalysis
Creatinine