Korean J Hematol.  2009 Jun;44(2):113-116. 10.5045/kjh.2009.44.2.113.

A Case of Immune Thrombocytopenic Purpura Developing after Treatment for Non-Hodgkin's Lymphoma

• Lee HY
• Jeong DJ
• Lee DG
• Chun K
• Ryu SW
• Song SY

• KMID: 2252157
• DOI: http://doi.org/10.5045/kjh.2009.44.2.113

Abstract

Immune thrombocytopenic purpura (ITP) can be classified as primary or secondary according to the presence of an underlying non-malignant or malignant disorder, including lymphoproliferative disorders. The estimated prevalence of ITP in patients with Hodgkin's lymphoma is about 1%, and its clinical course has been reported in approximately 50 patients. ITP is an unusual and poorly documented complication in patients with non-Hodgkin's lymphoma. Some cases have been described in patients who have undergone high-dose chemotherapy and autologous bone marrow/peripheral blood stem cell transplantation. Rare cases appear to be coincidental. Here, we report on a rare case of a 61-year-old man who had ITP after being in a state of complete remission of non-Hodgkin's lymphoma for about 15 months.

Keyword

Idiopathic thrombocytopenic purpura; Non-Hodgkin's lymphoma; Splenectomy

MeSH Terms

Hodgkin Disease
Humans
Lymphoma, Non-Hodgkin
Lymphoproliferative Disorders
Middle Aged
Prevalence
Purpura, Thrombocytopenic, Idiopathic
Splenectomy
Stem Cell Transplantation

Figure

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  Fig. 1. Peripheral blood shows marked thrombocytopenia (Wright-Giemsa stain, ×200).

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  Fig. 2. Computed tomography (CT) scan demonstrates multiple enlarged lymph nodes at lymphoma diagnosis (A). Follow-up CT scan shows no evidence of newly developed lesions (B).

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  Fig. 3. PET-CT scan shows no abnormal focal FDG uptake.

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  Fig. 4. Bone marrow finding showing adequate number and normal morphology of magakaryocytes. There are no aggregates or infiltrates of large lymphoid cells in the marrow space (H&E stain, ×200).

Reference

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