Korean J Hematol.  2009 Sep;44(3):172-176. 10.5045/kjh.2009.44.3.172.

A Case of Multicentric Castleman's Disease Diagnosed with Lymph Node Biopsy and Bone Marrow Examination

• Park SH
• Park CJ
• Huh J
• Jang S
• Chi HS
• Suh C

• KMID: 2252138
• DOI: http://doi.org/10.5045/kjh.2009.44.3.172

Abstract

Castleman's disease (CD) is an uncommon lymphoproliferative disorder presenting with a variable spectrum of clinical manifestations. CD is classified into two subtypes, Localized CD and Multicentric CD, by clinical manifestation, and is divided into 2 histopathologic types: a hyaline-vascular type (HV) or a plasma-cell type (PC). Multicentric CD show PC type predominantly and show systemic symptoms, such as fever, night sweat, malaise, ascites, edema, and more than half show multiple lymphadenopathy and hepatosplenomegaly. We report a case of 67 year old man with multicentric CD presented with fever of unknown origin and diagnosed with lymph node biopsy and bone marrow examination with a brief review of the literature.

Keyword

Multicentric Castleman's disease; Lymph node biopsy; Bone marrow examination

MeSH Terms

Ascites
Biopsy
Bone Marrow
Bone Marrow Examination
Edema
Fever
Fever of Unknown Origin
Giant Lymph Node Hyperplasia
Lymph Nodes
Lymphatic Diseases
Lymphoproliferative Disorders
Sweat
Giant Lymph Node Hyperplasia

Figure

• 

  Fig. 1. A large fibronodular granulomatous lesion composed of small lymphocytes, spindle cells, histiocytes and plasma cells (A and B) and megakaryocytic hyperplasia with frequent cluster formation (C) on bone marrow biopsy (H&E stain, (A) ×200, (B) ×400, (C) ×400).

• 

  Fig. 2. Interstitial polyclonal plasma cell hyperplasia with CD138 positivity and lambda light chain predominance (Immunohistochemistry, ×400, A) CD138, (B) kappa light chain, (C) lambda light chain.

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  Fig. 3. An angiomyoproliferative lesion on lymph node biopsy (H&E stain, ×200).

Reference

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