Prognostic factors of breast cancer in Koreans

Kim, Hark Kyun; Bang, Soo Mi; Byun, Jae Ho; Ryu, Min Hee; Lee, Won Sup; Lee, Keun Seok; Jeong, Joo Young; Kim, Jee Hyun; Lee, Se Hoon; Na, Im Il; Heo, Dae Seog; Bang, Young Jue; Kim, Noe Kyeong

Abstract

BACKGROUND
The aim of this study is to determine prognostic factors of breast cancer in Korean patients who underwent curative mastectomy.
METHODS
Medical records of 181 patients who underwent curative mastectomy were reviewed. Relapse-free survival and overall survival were documented for each patient. Factors influencing survival were analyzed using Cox proportional hazard model.
RESULTS
Overall 5-year survival rate was 82.0%, and 8-year survival rate was 74.7%. Multivariate analysis indicated that multiple axillary lymph node involvement (> or =4), postmenopausal status, and negative estrogen receptor were independent adverse prognostic factors. The adjusted relative risks of multiple axillary lymph node involvement (> or =4), postmenopausal status, and negative estrogen receptor were estimated 2.60 (95% Confidence Interval (CI): 1.28-5.30), 2.64 (95% CI: 1.46-4.79), and 2.27 (95% CI: 1.19-4.35), respectively.
CONCLUSION
Multiple axillary lymph node involvement (> or =4), postmenopausal status, and negative estrogen receptor were independent adverse prognostic factors in Korean breast cancer patients after curative mastectomy.