Korean J Biol Psychiatry.
2016 Feb;23(1):24-28. 10.0000/kjbp.2016.23.1.24.
Role of p11 (S100A10) in Depression and Antidepressant Effects
- Affiliations
-
- 1Paik Institute for Clinical Research, Inje University College of Medicine, Busan, Korea. neuro109@hanmail.net
- 2Department of Health Science and Technology, Graduate School of Inhe University, Busan, Korea.
- 3Department of Psychiatry, Haeundae Paik Hospital and College of Medicine, Inje University, Busan, Korea.
- KMID: 2251108
- DOI: http://doi.org/10.0000/kjbp.2016.23.1.24
Abstract
- p11 protein (S100A10) is downregulated in depressive-like states of human and rodent. Antidepressant drug treatment increases p11 levels in rodent models. We reviewed studies demonstrating that p11 levels are regulated in depression and by antidepressant treatment and that p11 upregulation exerts antidepressant effects. Current studies on p11 underscore the importance of p11 as a potential antidepressant target.
