Korean J Dermatol.  2001 Dec;39(12):1432-1434.

Two Cases of Lichen Nitidus Treated with Diphenylcyclopropenone Immunotherapy

• Lee SD
• Kim MY
• Baek SC
• Houh D
• Byun DG

Abstract

Lichen nitidus is a rare, usually asymptomatic chronic inflammatory dermatosis composed of numerous, tiny, discrete, flesh colored, shiny papules. Since the disease is asymptomatic and self-limiting, the specific treatment is not required in most cases. But when the lesion is generalized, symptomatic, persistent, interfering with outlook, the treatment is required. Diphenylcyclopropene (DPCP), a potent contact sensitizing agent has been used for refractory wart and alopecia areata based on its ability to induce delayed hypersensitivity reaction or nonspecific cell-mediated immunity. We report two cases of lichen nitidus improved after topical DPCP application.

Keyword

Lichen nitidus; Diphenylcyclopropene

MeSH Terms

Alopecia Areata
Hypersensitivity, Delayed
Immunity, Cellular
Immunotherapy*
Lichen Nitidus*
Lichens*
Skin Diseases
Warts