Korean J Dermatol.
2005 Oct;43(10):1383-1387.
A Case of Biphasic Amyloidosis in Systemic Sclerosis
- Affiliations
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- 1Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea. drkmp@hanmail.net
- 2Bon Skin Clinic, Busan, Korea.
Abstract
- Primary cutaneous amyloidosis is a disorder in which amyloid deposition occurs in the skin without associated deposits in internal organs. The most common types are macular amyloidosis and lichen amyloidosis. The co-occurrence of both types is termed biphasic amyloidosis and has rarely been reported so far. Moreover, only a few cases of amyloidosis development in the patients of systemic sclerosis have been reported. e report a 42-year-old female with systemic sclerosis, presented with pruritic skin lesions with hyperpigmentation on the back and lower extremities. Histopathologic examination revealed amyloid deposits which were restricted to the upper dermis and confirmed by Congo red staining, polarizing microscopy and transmission electron microscopy. There was no evidence of systemic amyloidosis.
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