Korean J Dermatol.
2006 May;44(5):655-657.
A Case of Extramammary Paget's Disease Treated with 5% Imiquimod Cream
- Affiliations
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- 1Department of Dermatology, Bundang CHA General Hospital, College of Medicine, Pochon CHA University, Sungnam, Korea. titoarch@hotmail.com
Abstract
- Extramammary Paget's disease (EMPD) is an uncommon malignancy involving the epidermis, which sometimes extends into the dermis. Current treatments for EMPD are surgical excision, Mohs micrographic surgery, or laser ablation. We report a case of a 50-year-old man who presented with EMPD. The patient refused to undergo surgery and, as an alternative, he applied 5% imiquimod cream, an immune response modifier, on a daily basis for 8 months. During the initial weeks of therapy, he experienced moderate erythema and flu-like symptoms. However, imiquimod treatment resulted in clinical and histological eradication of EMPD after 8 months with no recurrence during the 18 month follow-up period.
