Korean J Dermatol.  2006 May;44(5):642-644.

A Case of Aplasia Cutis Congenita after Methimazole Exposure during Pregnancy

• Park G
• Kim HJ
• Jang HC
• Chung H

Abstract

Aplasia cutis congenita is a rare congenital defect in which localized or widespread areas of the skin are singly or multiply absent or already scarred at birth. Multiple etiologies have been suggested for the cause, however, methimazole exposure during pregnancy has rarely been postulated as the cause of aplasia cutis congenita. We report a case of an infant with scalp aplasia cutis congenita, whose thyrotoxic mother was treated with methimazole during the first 9 weeks of gestation. The casual relationship between the drug and the skin defect is still a matter of debate, therefore, propylthiouracil treatment appears to be preferable to methimazole during the fertile period.

Keyword

Aplasia cutis congenita; Methimazole

MeSH Terms

Cicatrix
Congenital Abnormalities
Ectodermal Dysplasia*
Female
Fertile Period
Humans
Infant
Methimazole*
Mothers
Parturition
Pregnancy*
Propylthiouracil
Scalp
Skin
Methimazole
Propylthiouracil