Korean J Dermatol.  2007 Nov;45(11):1180-1182.

A Case of Acneiform Eruption and Paronychia Occurring after Use of Erlotinib (Tarceva(R))

• Yeon JH
• Min SU
• Lee DH
• Choi YS
• Suh DH

Abstract

Erlotinib (Tarceva(R)) is a new anti-cancer agent which acts by inhibiting epidermal growth factor receptor (EGFR) signal transduction. It is currently used in the treatment of advanced stage non-small cell lung cancer and pancreatic cancer. We report a case of acneiform eruption and paronychia induced by erlotinib in a 69-year-old man. The patient visited our clinic with multiple erythematous papules and pustules on the face, periungual erythema and pus discharge, xerosis, fissures on the sole. He had taken erlotinib for the treatment of recurred lung cancer for 4 weeks. The skin lesions were partially improved with oral pyridoxine, corticosteroid and topical antibiotics.

Keyword

Acneiform eruption; Erlotinib; Paronychia

MeSH Terms

Acneiform Eruptions*
Aged
Anti-Bacterial Agents
Carcinoma, Non-Small-Cell Lung
Erythema
Humans
Lung Neoplasms
Pancreatic Neoplasms
Paronychia*
Pyridoxine
Receptor, Epidermal Growth Factor
Signal Transduction
Skin
Suppuration
Erlotinib Hydrochloride
Anti-Bacterial Agents
Pyridoxine
Receptor, Epidermal Growth Factor