Korean J Infect Dis.  2000 Feb;32(1):73-77.

A Case of Disseminated Mucormycosis after Allogenic Bone Marrow Transplantation

• Kim SH
• Kim KB
• Choo YM
• Chang WI
• Kim YS
• Lee DG
• Choi JH
• Shin WS
• Min CK
• Kim CC

Abstract

Disseminated mucormycosis is a rare fungal infectious disease with a high mortality rate and is infrequently diagnosed ante mortem. It is most frequently seen in immunocompromised hosts such as diabetes mellitus, hematologic malignancies, or in the long-term use of steroids or chemotherapeutic agents. Tissue invasion by the hyphae of mucormycosis must be seen microscopically to establish the diagnosis. Treatment consists of correction of the predisposing condition, surgical debridement, and amphotericin-B therapy. A 35-year-old man was admitted through the emergency room due to fever and the right flank pain. He had received an allogenic bone marrow transplantation eight months ago and had been medicated with prednisolone and cyclosporine since the procedure. He was diagnosed with disseminated mucormycosis that involved the spleen, right kidney, and right lung. He is being successfully treated with amphotericin B, flucytosine, and liposomal amphotericin B.

Keyword

Mucormycosis; Immunocompromised host; Amphotericin B; Liposomal amphotericin B

MeSH Terms

Adult
Amphotericin B
Ants
Bone Marrow Transplantation*
Bone Marrow*
Communicable Diseases
Cyclosporine
Debridement
Diabetes Mellitus
Diagnosis
Emergency Service, Hospital
Fever
Flank Pain
Flucytosine
Hematologic Neoplasms
Humans
Hyphae
Immunocompromised Host
Kidney
Lung
Mortality
Mucormycosis*
Prednisolone
Spleen
Steroids
Amphotericin B
Cyclosporine
Flucytosine
Prednisolone
Steroids