Korean J Dermatol.  2008 Oct;46(10):1402-1406.

A Case of Early Stage Mycosis Fungoides that was Successfully Treatedwith a Combination Therapy of PUVA and Interfernon-gamma

• Yoo KH
• Kim YJ
• Rho YK
• Park JH
• Kim JY
• Li K
• Seo SJ
• Hong CK

Abstract

Early stage mycosis fungoides (MF) is known to be responsive to various topical and systemic therapies such as corticosteroids and ultraviolet light radiation, photochemotherapy with psoralens and whole-body electron beam irradiation. However, these treatments have all revealed a high relapse rate. Thus, we suggest that more invasive therapy, including PUVA combined with interferon-gamma, is one of the possible treatments for early MF because this treatment displays a reduced relapse rate. We report here on a case of early stage MF (Stage Ib) that was successfully treated with PUVA (total dose: 105.7 J/cm2) and intravenous administration of recombinant human interferon-gamma (total 5.4x10(6) IU), and the patient has been without relapse 1 year after treatment.

Keyword

Early stage mycosis fungoides; Interfernon-gamma; PUVA

MeSH Terms

Administration, Intravenous
Adrenal Cortex Hormones
Electrons
Ficusin
Humans
Interferon-gamma
Mycosis Fungoides
Photochemotherapy
Psoralens
Recurrence
Ultraviolet Rays
Adrenal Cortex Hormones
Ficusin
Interferon-gamma
Psoralens