Korean J Dermatol.
2009 Mar;47(3):295-302.
An Open Label, Multi-center Clinical Trial of Topical 5% Minoxidil Solution for the Treatment of Male Androgenetic Alopecia (A Phase IV Study)
- Affiliations
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- 1Department of Dermatology, Yonsei University Wonju College of Medicine, Korea. leewonsoo@yonsei.ac.kr
- 2Department of Dermatology, Chungnam National University Hospital, Korea.
- 3Department of Dermatology, Kyungpook National University School of Medicine, Korea.
- 4Department of Dermatology, Myoungji Hospital, Kwandong University College of Medicine, Korea.
- 5Department of Dermatology, Kyung Hee University East-West Neo Medical Center, Korea.
- 6Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Korea.
- 7Department of Dermatology, College of Medicine, Inha University, Korea.
- 8Department of Dermatology, Kangnam St Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea.
- 9Department of Dermatology, Seoul National University Bundang Hospital, Korea.
- 10Department of Dermatology, Chungbuk National University Hospital, Korea.
- 11Department of Dermatology, College of Medicine, Pusan National University, Korea.
- 12Department of Dermatology, Dong-a University Hospital, Korea.
- 13Department of Dermatology, Korea University Guro Hospital, Korea.
- 14Department of Dermatology, Chonnam National University Hospital, Korea.
Abstract
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BACKGROUND: Topical 5% minoxidil solution stimulates new hair growth and it helps stop the loss of hair on individuals with androgenetic alopecia (AGA).
OBJECTIVE
We wanted to assess the efficacy and safety of topical 5% minoxidil solution for treating Korean men with AGA.
METHODS
This was a 24-week, open label, clinical trial that was conducted at 14 university dermatologic centers nationwide throughout South Korea as a multicenter study of the Korean Hair Research Society. The eligible subjects for this study were 18- to 65 year-old men with androgenetic alopecia, as defined by the Norwood scale as type III vertex, IV and IVA. A total of 175 men (20~62 years old) with AGA applied topical 5% minoxidil solution twice daily. Efficacy was evaluated by 1) the total hair count per 1 cm2 and 2) the mean hair diameter and 3) the patient assessment and 4) the investigator assessment of the change in scalp coverage and the benefit of treatment.
RESULTS
At week 24 as compared with baseline, there was a statistically significant increase in the total hair counts and the mean hair diameter (p<.0001). Topical 5% minoxidil solution helped improve the investigator and patient assessments. The topical 5% minoxidil solution was well tolerated over a 24-week period.
CONCLUSION
We believe that topical 5% minoxidil solution is a safe and effective drug for Korean men with AGA.
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