Korean J Dermatol.
2009 May;47(5):583-587.
A Case of Zosteriform Kaposi's Sarcoma after Prednisolon Treatment
- Affiliations
-
- 1Department of Dermatology, Soonchunhyang University Hospital, Seoul, Korea. Mkcho2001@hanmail.net
- 2Department of Plastic Surgery, Soonchunhyang University Hospital, Seoul, Korea.
- 3Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
- 4Department of Otorhinolaryngology-Head andNeck Surgery, Soonchunhyang University Hospital, Seoul, Korea.
Abstract
- Kaposi's sarcoma is a rare lympho-angioproliferative neoplasm with four types of variants: classic, iatrogenic immunosuppressive drug-associated, AIDS-related and Africa-endemic Kaposi's sarcoma. Most immunosuppressive drug- associated Kaposi's sarcomas usually occur after a kidney transplant or after receiving immunosuppressive therapy. A 64-year-old female patient showed numerous purpuric nodules and smaller erythematous plaques on the right lower leg for three months. Previously, the patient was treated with an immunosuppressive drug for rapidly progressive glomerulonephritis for a five-week period. A skin biopsy was performed under the clinical diagnosis of Kaposi's sarcoma. We performed immunohistochemical staining and polymerase chain reaction to detect human herpes virus 8 (HHV-8). We report a case of iatrogenic immunosuppressive drug-associated zosteriform Kaposi's sarcoma that rapidly occurred five weeks after prednisolon therapy in a rapidly progressive glomerulonephritis patient.
