J Gynecol Oncol.  2009 Jun;20(2):86-90. 10.3802/jgo.2009.20.2.86.

Role of high risk-human papilloma virus test in the follow-up of patients who underwent conization of the cervix for cervical intraepithelial neoplasia

• Park JY
• Bae J
• Lim MC
• Lim SY
• Lee DO
• Kang S
• Park SY
• Nam BH
• Seo SS

• KMID: 2245089
• DOI: http://doi.org/10.3802/jgo.2009.20.2.86

Abstract

OBJECTIVE
To examine whether the presence of high risk-human papilloma virus (HR-HPV) after conization of the cervix was a risk factor for persistence or recurrence of cervical intraepithelial neoplasia (CIN) and whether HR-HPV test could be a guideline for post-therapy surveillance.
METHODS
The study retrospectively analyzed data from 243 patients who underwent LLETZ or CKC of the cervix due to CIN.
RESULTS
A positive HR-HPV test result which was performed between 3 and 6 months after procedure was a risk factor for persistent or recurrent cytological (p<0.001, odds ratio [OR]=22.51, 95% confidence interval [CI]=9.74-52.02) and pathological (p<0.001, OR=18.28, 95% CI=5.55-60.20) abnormalities.
CONCLUSION
HR-HPV positive patients between 3 and 6 months after procedure should undergo frequent and meticulous post-therapy surveillance, while HR-HPV negative patients do not require such high-level surveillance and could undergo routine surveillance.

Keyword

HR-HPV; Conization; CIN; Recurrence

MeSH Terms

Cervical Intraepithelial Neoplasia
Cervix Uteri
Conization
Female
Follow-Up Studies
Humans
Odds Ratio
Papilloma
Recurrence
Retrospective Studies
Risk Factors
Viruses

Figure

• 

  Fig. 1 Persistent or recurrent (A) cytological (left, p<0.001) or (B) pathological (right, p<0.001) abnormalities according to HR-HPV test results between 3 and 6 months after LLETZ or CKC. HR-HPV: high risk-human papilloma virus, LLETZ: large loop excision of transformation zone, CKC: cold knife conization.

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