Clinical Characteristics and Treatment Modalities in Uterine Sarcoma

Son, Sung Kyong; Lee, Jin Gu; Jung, Gu Hyun; Kang, Byung Hun

Abstract

OBJECTIVE
: The purpose of this study was to investigate the clinicopathologic findings, treatment modalities and outcomes of patients with uterine sarcoma.
METHODS
: From Jan. 1984 to Dec. 2003, 30 patients with uterine sarcoma managed in the Department of Obstetrics and Gynecology of Chungnam National University Hospital were evaluated for their clinical profiles and survival.
RESULTS
: The mean age of patients with uterine sarcoma was 51 years. The most common presenting symptom was abnormal uterine bleeding, and the most common pathologic type of uterine sarcoma was leiomyosarcoma. Using the FIGO surgical staging criteria, we found the following distribution; 26 cases (86.7%) stage I, 2 cases (6.7%) stage III, 2 cases (6.7%) stage IV. The patients with uterine sarcoma were treated by surgery, adjuvant radiotherapy and chemotherapy. The 2 year survival rate was 74.1% and The 5 year survival rate was 67.4%. Recurrences developed in 11 patients. The most common recurrence site was lung.
CONCLUSION
: Uterine sarcoma is an aggressive tumor with a poor prognosis. The major treatment is surgery and the role of adjuvant chemotherapy or radiotherapy still remains undetermined. Our data showed excellent outcome in early disease and further large scaled multicenter studies are needed.