Korean J Hepatobiliary Pancreat Surg.
2001 Dec;5(2):113-117.
Hepatocellular Carcinoma of the Liver with Sarcomatous Feature
- Affiliations
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- 1Department of General Surgery. Medical College of Kosin, Gospel Hospital Chang Kee Ryo Memorial Liver Institute.
- 2Department of Anatomic Pathology. Medical College of Kosin, Gospel Hospital Chang Kee Ryo Memorial Liver Institute.
- 3Department of Diagnostic Radiology. Medical College of Kosin, Gospel Hospital Chang Kee Ryo Memorial Liver Institute.
Abstract
- One case of hepatocellular carcinoma with sarcomatous changes is presented. Histologically, the tumor was composed of hepatocellular-carcinomatous and sarcomatous components, including trabecular, pseudoglandular, and spindle-shaped varieties. There was a transitional cell form between the carcinoma and sarcomatous cells. Immunohistochemical examination for alpha-feto protein reveals positive staining in hepatocellular carcinoma component, and vimentin had positive result in most spindle-shaped sarcomatous cells and some epithelial tumor cells, whereas cytokeratin and EMA(epithelial membrane antigen) revealed negative staining in tumor cells, On the basis of this findings, the possibility of sarcomatous transformation of hepatocellular carcinoma was discussed.
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