Korean J Hepatobiliary Pancreat Surg.
2003 Jun;7(1):32-36.
A Comparison of the Clinicopathologic and Prognostic Differences in Patients Who Underwent Hepatic Resection with Hepatitis B- versus Hepatitis C-related Hepatocellular Carcinoma
- Affiliations
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- 1Department of Surgery, Kyungpook National University Hospital, Daegu, Korea. longus75@daum.net
- 2Department of Biomolecular Engineering Center, Kyungpook National University Hospital, Daegu, Korea.
Abstract
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BACKGROUND/AIMS: The surgical outcomes for patients with HCC according to different hepatitis viral status have been inconsistently reported. This study evaluated the clinico-pathological and prognostic differences in patients with HBV- and HCV-related HCC.
METHODS
Two hundred and eleven patients with HCC who underwent curative hepatic resection were categorized into three groups according to viral status: Group I (Hbs Ag (+) HCV Ab (-), n=116); Group II (Hbs Ag (-) HCV Ab (+), n=74); Group III (Hbs Ag (-) HCV Ab (-), n=17). The clinical manifestations, pathologic features, and treatment outcomes were compared.
RESULTS
The average age at onset of HCV-related HCC is older than that of HBV-related HCC. Most HCV-related HCC is associated with liver cirrhosis as reflected by lower albumin level, platelet count, higher ICG R15 value, ALT levels. and frequency of minor resection (P<0.05). The incidence of portal vein invasion or intrahepatic metastasis did not differ among groups. In addition, HCV Ab (+) group had significantly lower disease free survival rates (P<0.05).
CONCLUSION
This study suggests that the patients with HCV- related HCC have poorer liver function with more frequent recurrence.