Korean J Hepatobiliary Pancreat Surg.  2013 Feb;17(1):34-37. 10.14701/kjhbps.2013.17.1.34.

Primary hepatic neuroendocrine carcinoma

• Kim JM
• Kim SY
• Kwon CH
• Joh JW
• Park JB
• Lee JH
• Kim SJ
• Park CK

• KMID: 2243166
• DOI: http://doi.org/10.14701/kjhbps.2013.17.1.34

Abstract

A 67-year-old woman was admitted to our hospital under suspicion of a hepatic tumor, which had been previously diagnosed to be an adenocarcinoma by fine needle aspiration. Computed tomography and magnetic resonance imaging revealed a large tumor measuring 9 cm in diameter in Couinaud's hepatic segments 4, 5, and 8. We diagnosed the patient to have primary liver cancer, and suspected intrahepatic cholangiocarcinoma preoperatively. We performed a central hepatectomy. According to the immunohistochemical findings of the resected specimen, the tumor was diagnosed to be a primary neuroendocrine carcinoma in the liver. The patient is presently alive without recurrence at 3 months after hepatic resection.

Keyword

Liver malignancy; Hepatectomy; Neuroendocrine carcinoma; Chromogranin A

MeSH Terms

Adenocarcinoma
Biopsy, Fine-Needle
Carcinoma, Neuroendocrine
Cholangiocarcinoma
Chromogranin A
Female
Hepatectomy
Humans
Liver
Liver Neoplasms
Magnetic Resonance Imaging
Recurrence
Chromogranin A
Liver Neoplasms

Figure

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  Fig. 1 MRI scan images of a primary hepatic neuroendocrine carcinoma patient.

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  Fig. 2 Pathologic examination of primary hepatic neuroendocrine carcinoma. (A) The tumor was 10.5×10 cm size; (B) hematoxylin-eosin staining showing tumor cells (original magnification ×200); (C-E) immunohistochemical staining for CD56 (C), chromogranin A (D), and synaptophysin (E) (original magnification ×200).

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