Influence of Etiological Factors on the Prognosis and Severity in Acute Pancreatitis

Hyun, Jin Hai; Lee, Sang Woo; song, Chi Wook; Ryu, Ho Sang; Kim, Chang Duck; Jeen, Yoon Tae; Kim, Kwang Hee; Lee, Hong Sik; Lee, Sung Joon; Park, Heung Jin; Chun, Hoon Jai; Um, Soon Ho; Choi, Jai Hyun

Abstract

Background/Aims,: The clinical severity of gallstone pancreatitis is known to be more intense than that of alcoholic pancreatitis. However, it is still controversial whether the etiology is risk factors for the pronosis of acute pancreatitis (AP). This study was designed to elucidate the role of etiological factors on the prognosis and severity in AP.
METHODS
We have retrospectively evaluated 216 patients (M:137, F:79) with AP during recent 6 years. The diagnosis of AP was based on the typical symptoms and signs, enzyme elevation and radiologic findings. Acute physiology and chronic health evaluation (APACHE II) and Ranson score at admission were used for grading the severity. Etiological groups were subdivided into alcohol, gallstone, idiopathic and others.
RESULTS
The causes of AP were alcohol (32.4%), gallstone (26.9%), idiopathic (23.1%) and others (17.6%). The clinical severity was not different between alcohol and gallstone pancreatitis. The mortality rate was 10% in patients with alcoholic pancreatitis, but no death was seen in patients with gallstone pancreatitis.
CONCLUSIONS
The alcoholic pancreatitis was not severe than the gallstone pancreatitis in clinical severity, but the complication and mortality of the alcoholic pancreatitis were higher than those of the gallstone pancreatitis. The prognosis and mortality were influenced by etiological factors in AP.