Effects of Gelatin Administration on Acute Hemorrhage in Cats

Cho, Hun; Kim, Byeong Yong; Lee, Hye Won; Chae, Byung Kook; Chang, Seong Ho; Shin, Jung Soon

Abstract

Recently there has been renewed interest in the use of highly concentrated saline solutions and colloidal fluid to resuscitate animals and humans from hypovolemic shock. In this study, effects of resuscitation with various fluids were compared in a cat model of acute hemorrhage. After anesthesia, the cat was exanguinated from the femoral artery, and an equivalent amount of fluid was injected through the femoral vein. Therefore this study was performed to evaluate the effects of gelatin in comparison with others. The results were as follows 1) Compared to crystalloid solution, colloidal soluions were more effective in restoring hemodynamic disturbance but there were no significant differences between Gelatin and Dextran group at same dosage level. 2) Mean arterial pressure was significantly increased in dextran and gelatin group after 30 minutes of fluid resuscitation(p<0.05). 3) Decreased hemoglobin due to plasma volume expansion was noticed in all group's(p<0.05) 4) After replacement of dextran and gelatin, central venous pressure was restored effectively(p < 0.05). 5) Decreased ETCO was recovered after replacement of fluid, but no difference among three groups. 6) Increased potassium level was redecreased 30 minutes after replacement of gelatin(p < 0.05). 7) Sodium level was decreased after hemorrhange in all three groups and after replacement of H/D and dextran, but no change in gelatin group(p<0.05). 8) Increased lactate after hemorrhage was decreased in gelatin and dextran group. 8) Decreased pH restored after replacement of dextran and gelatin.