Korean J Anesthesiol.  1996 Oct;31(4):442-447. 10.4097/kjae.1996.31.4.442.

The Effects of Urapidil on Changes of Arterial Blood Pressure and Heart Rate to Endotracheal Intubation

• Lim JG
• Yang HS
• Kim YC
• Dun SB
• Shin CK

• KMID: 2240349
• DOI: http://doi.org/10.4097/kjae.1996.31.4.442

Abstract

BACKGROUND: Urapidil is a new antihypertensive agent known to diminish total peripheral vascular resistance by postsynaptic alpha 1-adrenergic blockade and central sympatholytic activity. The purpose of this study was to determine its effectiveness and safety in preventing hemodynamic responses to endotracheal intubation under general anesthesia.
METHODS
Thirty normotensive, ASA physical status I patients for elective surgery were selected randomly. They were divided into three groups(Group 1: control group with saline, Group 2: urapidil 0.4 mg/kg, Group 3: urapidil 0.5 mg/kg, n=10 in each group). The drugs were injected 3 minutes before induction with thiopental sodium(4 mg/kg) and succinylcholine(1 mg/kg). Endotracheal intubation was performed 5 minutes after the drugs injection. After endotracheal intubation, vecuronium 0.1 mg/kg was injected and 50% nitrous oxide in oxygen and 2Vol% enflurane were inhaled. We measured the blood pressure and the heart rate with noninvasive method at one minute interval for 5 minutes.
RESULTS
In group 3, no significant increase in systolic blood pressure after endotracheal intubation was noted(p<0.05). Urapidil groups showed increase in heart rate at 1, 2 minutes after urapidil injection(p<0.05) and did not blunt increase in heart rate after endotracheal intubation. The side effects of urapidil(hypotension, dizziness, headache and chest tightness) occured in a patient of group 3.
CONCLUSIONS
We found that the blood pressure response was effectively controlled, but the change in heart rate was not controlled by urapidil 0.5 mg/kg injection before induction.

Keyword

Blood pressure; Heart heart rate; Intubation; tracheal; Sympath-etic nervous system pharmacology; urapidil

MeSH Terms

Anesthesia, General
Arterial Pressure*
Blood Pressure
Dizziness
Enflurane
Headache
Heart Rate*
Heart*
Hemodynamics
Humans
Intubation
Intubation, Intratracheal*
Nitrous Oxide
Oxygen
Thiopental
Thorax
Vascular Resistance
Vecuronium Bromide
Enflurane
Nitrous Oxide
Oxygen
Thiopental
Vecuronium Bromide