Korean J Gastroenterol.
2000 Apr;35(4):422-428.
The Influence of Number of Gastroscopic Biopsy Specimens on Follow-up Campylobacter-Like Organism (CLO) Test
Abstract
- BACKGROUND/AIMS
The accurate detection of Helicobacter pylori (H. pylori) after triple therapy is needed for effective control of H. pylori-infected gastrointestinal diseases. This study was designed to determine whether the increased number of biopsy specimens improved the sensitivity of CLO test after eradication treatment. METHODS:A total of 196 patients with H. pylori-infected peptic ulcer were enrolled. Gastroscopic examinations were performed before and after triple therapy (4-6 weeks after therapy) for CLO test, histology, and polymerase chain reaction (PCR). In group 1 (n=73), nine biopsy specimens were taken from the antrum, the angle, and the midbody (2 for CLO test, 2 for PCR 5 for histology). In group 2 (n=123), eleven biopsy specimens were taken from the antrum and the midbody (4 for CLO test, 2 for PCR, 5 for histology).
RESULTS
The age, sex, and treatment regimens of both groups were similar. The sensitivities of follow-up CLO test in group 1 and 2 were 56% and 85% (p=0.0325), and the specifities were 100% and 98%, respectively (p=0.543).
CONCLUSIONS
The increased number of biopsy specimens may improve the sensitivity of CLO test after H. pylori triple therapy.
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