Korean J Anesthesiol.  1999 Sep;37(3):431-435. 10.4097/kjae.1999.37.3.431.

A Comparison of the Effects of Ondansetron and Granisetron on the Prevention of Postoperative Nausea and Vomiting after Gynecologic Surgery

• Choi IH
• Oh JI
• Do SW

• KMID: 2240044
• DOI: http://doi.org/10.4097/kjae.1999.37.3.431

Abstract

BACKGROUND: The purpose of this study was to compare the effects of ondansetron and granisetron on the prevention of postoperative nausea and vomiting (PONV) in gynecologic patients.
METHODS
In a randomized placebo-controlled study, 200 gynecologic patients were divided into 5 groups. Each patient received one of 5 medications: placebo (saline 3 ml), ondansetron 4 mg (O4), ondansetron 8 mg (O8), granisetron 1.5 mg (G1.5) and granisetron 3 mg (G3). They were administered intravenously immediately before the induction of anesthesia. A standardized inhalation anesthesia and a postoperative intravenous patient-controlled analgesia were applied. Twenty four hours after anesthesia, the incidence and severity of PONV and other adverse effects were assessed.
RESULTS
The incidence of PONV was 88%, 83%, 75%, 70% and 60% in the placebo, O4, O8, G1.5 and G3 groups, respectively, which showed significantly lower value in the G3 group than in the placebo and O4 groups (P< 0.05). The severity of PONV was also significantly lower in the G3 group than in the placebo group (P < 0.05).
CONCLUSIONS
In this study, granisetron 3 mg showed a better prophylactic effect in the mitigation of PONV in gynecologic patients then a placebo or ondansetron 4 mg.

Keyword

Analgesia, patient-controlled (PCA); Complications, nausea, vomiting; Pharmacology, ondansetron, granisetron; Surgery, gynecologic

MeSH Terms

Analgesia, Patient-Controlled
Anesthesia
Anesthesia, Inhalation
Female
Granisetron*
Gynecologic Surgical Procedures*
Humans
Incidence
Ondansetron*
Postoperative Nausea and Vomiting*
Granisetron
Ondansetron