Korean J Anesthesiol.  2008 Mar;54(3):S35-S39. 10.4097/kjae.2008.54.3.S35.

Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats

• Chung WS
• Go YG
• Lee WH

• KMID: 2239836
• DOI: http://doi.org/10.4097/kjae.2008.54.3.S35

Abstract

BACKGROUND: Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain.By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats.
METHODS
5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg).Number of flinches was measured in a 5 minute interval for 1 hour.
RESULTS
Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1.
CONCLUSIONS
ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia.

Keyword

DMPO; formalin test; ROS

MeSH Terms

Animals
Central Nervous System Sensitization
Formaldehyde
Injections, Intraperitoneal
Nociception
Pain Measurement
Rats
Reactive Oxygen Species
Formaldehyde
Reactive Oxygen Species