Korean J Anesthesiol.  1988 Feb;21(1):151-156. 10.4097/kjae.1988.21.1.151.

The Effect of Extracorporeal Circulation on Serum Angiotensin Converting Enzyme ( SACE ) Levels

• Kim KS
• Choi MS
• Kim DS
• Shin KI

• KMID: 2239497
• DOI: http://doi.org/10.4097/kjae.1988.21.1.151

Abstract

It is well known that the pulmonary capillary endothelium is rich in angiotensin converting enzyme(ACE), which is released in the event of smoking, acute lung injury, or some lung diseases such as Gauchers disease and hypertension. Serum ACE levels may be clinically useful because they are reflections of pulmonary circulation. In order to evaluate the effect of extracorporeal circulation and pulmonary perfusion on serum ACE levels, we measured serum ACE level during prebypass, total bypass(5', 30', 60') and pulmonary perfusion (30', 60', 24 hrs.) in 10 open-heart patients. The results were as follows: 1) The SACE level before the begining of extracorporeal circulation was 10.03+/-1.66u/ml and decreased significantly to 2.79+/-0.63u/ml(p<0.005) 5min. after extracorporeal circulation was initiated. 2) The decreased SACE level seen during extracorporeal circulation returned to a nearly normal (9.33+/-1.8u/ml) 24hrs. after pulmonary perfusion. 3) There were no significant correlations between the SACE level and the variation of age during extracorporeal circulation and pulmonary perfusion. The above results suggest that SACE levels are proportional to the amount of pulmonary blood flow.

Keyword

Cardiovascular anesthesia; Angiotensin converting enzyme; Cardiopulmonary bypass

MeSH Terms

Acute Lung Injury
Angiotensins*
Cardiopulmonary Bypass
Endothelium, Vascular
Extracorporeal Circulation*
Gaucher Disease
Humans
Hypertension
Lung Diseases
Peptidyl-Dipeptidase A*
Perfusion
Pulmonary Circulation
Smoke
Smoking
Angiotensins
Peptidyl-Dipeptidase A
Smoke