Korean J Anesthesiol.  1991 Feb;24(1):96-103. 10.4097/kjae.1991.24.1.96.

The Effects of Body Posdition and Flow Rates on Pulmonary Oxygention during Constant Flow Ventilation in Apneic dogs

• Chung YK
• Song IH
• Lee HG

• KMID: 2239375
• DOI: http://doi.org/10.4097/kjae.1991.24.1.96

Abstract

In 7 apneic dogs, pulmonary gas exchange was compared between the supine and prone position during constant flow ventilantion (CFV) with room air or 100% oxygen at the different flow rate (5, 10, 15, 20 L/min). CFV was performed through two catheter (I.D. 2.0 mm) inserted into both main stem bronchi. The body position of the dogs was changed alternately and the order of flow rate selection was randomized. After 10 min. of each run of CFV, arterial blood gases were measured and alveolar arterial oxygen partial pressure difference (AaDO2) was calculated. AaDO2 with room air under the prone position was significantly smaller than that under the supine position at the flow rate of 5, 15 and 20 L/min. with increasing flow rate, AaDO2 with room air increased significantly regardless body position. No significant difference of AaDO2 with 100% oxygen were observed between the flow rate. The present study shows that ventilation perfusion (V/Q) mismatching during CFV in apneic dogs improved by changing the supine position to the prone position and deteriorated by increasing flow rates, which fact suggests that the impaired oxygenation during CFV is associated with the changes of the status of ventilation perfusion relationship, airway geometry and relative position of intrathoracic organ.

Keyword

Apnea; Constant flow ventilation; Oxygenation; Pulmonary gas exchange; Ventilation perfusion mismatching

MeSH Terms

Animals
Apnea
Bronchi
Catheters
Dogs*
Gases
Oxygen
Partial Pressure
Perfusion
Prone Position
Pulmonary Gas Exchange
Supine Position
Ventilation*
Gases
Oxygen