Korean J Anesthesiol.  1991 Feb;24(1):32-36. 10.4097/kjae.1991.24.1.32.

Neuromuscular Blocking Effects of Ketamine

• Kim JS
• Jeon JS
• Hwang KH
• Kim SC
• Kim SY

• KMID: 2239365
• DOI: http://doi.org/10.4097/kjae.1991.24.1.32

Abstract

In the human isolated arm preparation applied tourniquet on the upper arm, the neuromuscular blocking effects of ketamine were confirmed with the changes of first twitch height (T1) and train of four ratio (T4R) induced from 2Hz ulnar nerve stimulation (ABM Datex Co.) at 20 minutes after administration of ketamine. The results obtained were as follows; In the control group administered of saline, T1 was elevated to 6.48% compared with before tourniquet applied but T4R was not changed through the whole of the process. In the group I administered of ketamine 1 mg/kg, T1 and T,R were depressed of 8.68% and 29.59% respectively but T1 was not significant. In the group II administered of ketamine 2 mg/kg, T1 and T4R were depressed of 43.4% and 40.4% respectively. T1 and T4R in the group I and II were significantly depressed comparing with control group.

Keyword

Intravenous anesthetics; Ketamine; Neuromuscular blocking effect

MeSH Terms

Anesthetics, Intravenous
Arm
Humans
Ketamine*
Neuromuscular Blockade*
Tourniquets
Ulnar Nerve
Anesthetics, Intravenous
Ketamine