Korean J Anesthesiol.  1991 Jun;24(3):600-604. 10.4097/kjae.1991.24.3.600.

Effects of Chloral Hydrate ( Pocral ) Syrup as Oral Premedicants in Children

• Kim SD
• Do SH
• Lim SW

• KMID: 2239290
• DOI: http://doi.org/10.4097/kjae.1991.24.3.600

Abstract

The effects of oral chloral hydrate as the premedicant were evaluated in 87 children, scheduled for elective operations. They were all in ASA class 1 and were divided into 3 groups: group I for 10 mg/ kg, group II for 20 mg/kg and group III for 30 mg/kg of chloral hydrate syrup, respectively. The drug was adminsitered 1 hour before induction of anesthesia at the ward. On arrival at the operating room, anxiety levels, vital signs and side effects were evaluated by one observer. Their attitudes were observed just before induction of anesthesia. Hemodynamic variables such as blood pressure and heart rate were increased, probably due to increased sympathetic levels in spite of premedication. Respiratory rate was not changed in each group. The satisfactory anxiety levels checked by anxiety level 0 were 38%, 26% and 70% in group I, II and III, respectively. The attitudes at the operating rooms just before induction of anesthesia were satisfactory in 59%, 65% and 81% of group I, II and III, respectively. Side effects were about 10% in group II and III, but not in group I. We can conclude that adequate oral premedicant dose of chloral hydrate (Pocral) symp in children should be at least 30 mg/kg, one hour before induction of anesthesia.

Keyword

Chloral hydrate; Oral; Premedication; Children

MeSH Terms

Anesthesia
Anxiety
Blood Pressure
Child*
Chloral Hydrate*
Heart Rate
Hemodynamics
Humans
Operating Rooms
Premedication
Respiratory Rate
Vital Signs
Chloral Hydrate