Korean J Anesthesiol.  1994 Feb;27(2):120-127. 10.4097/kjae.1994.27.2.120.

Effects of thoracic epidural anesthesia on coronary blood flow and cardiovascular system in dogs

• Chang SH
• Lim HJ
• Kang YH
• Kim JU
• Chae BK

• KMID: 2239201
• DOI: http://doi.org/10.4097/kjae.1994.27.2.120

Abstract

We have been using general anesthesia with thoracic epidural anesthesia to manage intrao-perative and postoperative pain for thoracic and cardiac surgery patients. Hemodynamic changes due to sympathetic block with epidural anesthesia is dependent on the level of sympathetic block. Thoracic epidural anesthesia block the cardiac sympathetic innervation, so there may be changes of cardiac function and pressure dependent coronary blood flow especially in coronary artery diseases. To investigate the effects of thoracic epidural anesthesia on coronary blood flow and hemodynamic changes, we performed thoracic epidural anesthesia by injection of 0.5% bupivacaine via a surgieally introduced catheter in dogs. The results were as follows ; 1) Coronary blood flow, systolic, mean and diastolic blood pressure, heart rate and cardiac output were decreased at 5 min, 10 min, 15 min, 20 min, 30 min, 45 min, 60 min, 90 min, 120 min after epidural injection of 0.5% bupivaeaine compared to control value (p<0.05). 2) Systemie vascular resistance, central venous pressure, pulmonary artery pressure, pulmonary capillary wedge pressure, stroke volume and pulmonary vascular resistance were not changed after epidural injection of 0.5% bupivacaine.

Keyword

Thoracic epidural; Coronary blood flow; Cardiovascular system

MeSH Terms

Anesthesia, Epidural*
Anesthesia, General
Animals
Blood Pressure
Bupivacaine
Cardiac Output
Cardiovascular System*
Catheters
Central Venous Pressure
Coronary Artery Disease
Dogs*
Heart Rate
Hemodynamics
Humans
Injections, Epidural
Pain, Postoperative
Pulmonary Artery
Pulmonary Wedge Pressure
Stroke Volume
Thoracic Surgery
Vascular Resistance
Bupivacaine