Korean J Anesthesiol.  2004 Aug;47(2):198-204. 10.4097/kjae.2004.47.2.198.

The Effects of Dexmedetomidine on Hemodynamics and Plasma Catecholamine Concentrations during Coronary Artery Bypass Graft Surgery

• Hahm KD
• Ku SW
• Jeong YB
• Shin DH
• Choi IC

• KMID: 2237528
• DOI: http://doi.org/10.4097/kjae.2004.47.2.198

Abstract

BACKGROUND: Alpha-2 adrenergic agonists decrease the sympathetic tones of hemodynamic and endocrine responses to surgical stimuli. The goal of this study was to evaluate the hemodynamic and endocrinologic effects of intraoperatively administered dexmedetomidine, a highly selective alpha-2 adrenergic agonist, in patients undergoing coronary artery bypass graft surgery.
METHODS
Fifty coronary artery bypass graft patients, in a double-blind, randomized manner, received a continuous infusion of normal saline placebo or dexmedetomidine, 10 ng/kg/min for 1 hr from 5 minutes after sternotomy. All patients received standardized anesthesia. Plasma catecholamine was measured at 5 minutes after sternotomy (T1), 30 minutes after drug infusion (T2), and 30 minutes after drug cessation (T3). Heart rate, blood pressure, pulmonary artery pressure and cardiac output were monitored.
RESULTS
Compared with the placebo group, plasma norepinephrine concentrations decreased in the dexmedetomidine group Dexmedetomidine attenuated increased blood pressure on surgical stimuli and induced more hypotension.
CONCLUSIONS
The intraoperative infusion of dexmedetomidine to patients undergoing coronary artery bypass graft surgery reduced sympathetic tone and attenuated hemodynamic responses to surgical stimuli.

Keyword

coronary artery bypass graft surgery; alpha-2 adrenergic agonist; dexmedetomidine; catecholamine

MeSH Terms

Adrenergic Agonists
Anesthesia
Blood Pressure
Cardiac Output
Coronary Artery Bypass*
Coronary Vessels*
Dexmedetomidine*
Heart Rate
Hemodynamics*
Humans
Hypotension
Norepinephrine
Plasma*
Pulmonary Artery
Sternotomy
Transplants
Adrenergic Agonists
Dexmedetomidine
Norepinephrine