Local Cerebral Metabolic Changes During Halothane Anesthesia With Special Reference to Activated Nervous System

Lee, Hae Jin; Park, Chong Min

Abstract

The influence of Halothane on local cerebral glucose utilization was studid by quantitative autoradiography using 15 male Sprague-Dawley rats. The Rats had both the femoral artery and vein cannulated and anesthetized with 1.0 MAC and 2.0 MAC Halothane. Local cerebral glucose utilization (1-CMRg) was compared betweeen conscious control and the Halothane-anesthetized rat. The result was as follows; 1) There was a slight decrease of blood pressure in the anesthetized group, but it was within the range of autoregulation. The PaO2 and PaCO2 were influenced by artificial ventilation in anesthetized group but remained in normal range. 2) Fluctuation of 1-CMRg was noted according to the region during 1.0 MAC halothane anesthesia, the limbic system and basal ganglia showed increased 1-CMRg, but other discrete regions revealed decreased glucose utilization. Most regions showed decreased glucose utilization, except the subtantia nigra during 2.0 MAC halothane anesthesia. 3) The order of decreased glucose utilization was: Auditory system = Cerebral association area > Myelinated fiber > Sensory motor system > Limbic system > Extrapyramidal system in 1.0 MAC anesthesia group and Auditory system > Cerebral association area > Visual system > Sensory motor system > Limbic system = Extrapyramidal system > Myelinated fiber in 2.0 MAC anesthesia group. 4) Ther were no specific anatomical characteristics during 1.0 MAC or 2.0 MAC halothane anesth- esia. 5) Some regions showed increased glucose utilization during anesthesia which did not appeared in the conscious control animals. These regions were Habenulo-interpeduncular system, limbic system, and basal ganglia.