Korean J Anesthesiol.  1991 Oct;24(5):937-944. 10.4097/kjae.1991.24.5.937.

1.5 mg/Kg IV Lidocaine on the Catecholamine Response to Endotracheal Intubation

• Lee BH

• KMID: 2237090
• DOI: http://doi.org/10.4097/kjae.1991.24.5.937

Abstract

Increases in arterial blood pressure, heart rate and catecholamines are well known to be associated with laryngoscopy and intubation. Whether lidocaine is effective in attenuating these responses is controversial. The purpose of this study is to determine the effects of lidocaine on arterial pressu;e, heart rate, plasma epinephrine and norepinephrine levels following direct laryngoscopy and oral intubation. The results were as follows: 1) Mean arterial pressures and heart rates increased ca. 25% and 43%, respectively, at 1 minute post-intubation in both groups. 2) The mean epinephrine level increased 43% at I minute and then declined in the saline group, whereas the lidocaine group showed decreases of l3, 26, 43, 55 and 62% at l, 2, 3, 5 and 10 minutes, respectively. 3) Norepinephrine levels increased to 111, 113, 103, 87 and 48% at 1, 2, 3, 5 and 10 minutes for the saline group, whereas the increases were 72, 46, 35, 62 and 72/ for the lidocaine group. We conclude that in ASA l adult patients, 1.5 mg/Kg iv lidocaine administered (3 m) prior to laryngoscopy and oro-endotracheal intubation had no benficial clinical effect on the vital signs and catecholamine levels.

Keyword

Mean arterial pressure; Heart rate; Catecholamines; Laryngoscopy; Intubation; Lidocaine

MeSH Terms

Adult
Arterial Pressure
Catecholamines
Epinephrine
Heart Rate
Humans
Intubation
Intubation, Intratracheal*
Laryngoscopy
Lidocaine*
Norepinephrine
Plasma
Vital Signs
Catecholamines
Epinephrine
Lidocaine
Norepinephrine