Korean J Anesthesiol.  1992 Feb;25(1):114-120. 10.4097/kjae.1992.25.1.114.

Effects of Fentanyl - Oxygen Anesthesia on Serum Catecholamine during Open Heart Surgery

• Kim CS
• Bahk JH
• Kim ST
• Kim YC
• Kim KW

• KMID: 2237041
• DOI: http://doi.org/10.4097/kjae.1992.25.1.114

Abstract

Serum epinephrine and norepinephrine concentrations were measured in 7 patients during fentanyl-oxygen anesthesia, who were undergoing elective open heart surgery(single valvular replacement operations) in Seoul National University Hospital. Sampling times and corresponding total fentanyl doses were as follows; 1) after arterial cannulation 2) 5 minutes after intubation(50 ug/kg of B. Wt) 3) 5 minutes after sternotomy(65 ug/ka) 4) after aortic dissection(75 ug/kg) 5) 15 minutes after initiating bypass 6) 60 minutes after initiating bypass [20 ug/kg of fentanyl was added to the priming solution before initiation of Cardio-pulmonary bypass(CP bypass)]. High Performance Liquid Chromatography(HPLC) was used to analyze hormones. Epinephrine concentrations(pg/ml) corresponding to the sampling times were as follows (mean+/-SE); 1) 213+/-59 2) 199+/-62 3) 246+/-83 4) 173+/-35 5) 270+/-70 6) 269+/-70 Norepinephrine concentrations(pg/ml) were as follows(mean+/-SE); 1) 609+/-107 2) 500+/-73 3) 645+/-152 4) 470+/-82 5) 494+/-65 6) 955+/-311 There were no significant hormonal changes except the 6th norepinephrine value. There were no significant hemodynamic changes except blood pressure decrease at the beginning of CP bypass. It is concluded that high dose fentanyl-oxygen anesthesia was limitedly effective to block the stress of open heart surgery, general anesthesia and CP bypass.

Keyword

Anesthesia; Fentanyl; Open heart surgery; Norepinephrine; Epinephrine

MeSH Terms

Anesthesia*
Anesthesia, General
Blood Pressure
Catheterization
Epinephrine
Fentanyl*
Heart*
Hemodynamics
Humans
Norepinephrine
Oxygen*
Seoul
Thoracic Surgery*
Epinephrine
Fentanyl
Norepinephrine
Oxygen