Korean J Fam Med.  2013 May;34(3):199-205. 10.4082/kjfm.2013.34.3.199.

Non-alcoholic Fatty Liver Disease and Chronic Kidney Disease in Koreans Aged 50 Years or Older

• Ahn AL
• Choi JK
• Kim MN
• Kim SA
• Oh EJ
• Kweon HJ
• Cho DY

• KMID: 2235421
• DOI: http://doi.org/10.4082/kjfm.2013.34.3.199

Abstract

BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and many risk factors, and both are linked to an increased risk of cardiovascular diseases. The aim of this study was to assess the association between NAFLD and CKD according to the presence of hypertension and diabetes mellitus in Koreans aged 50 years or older.
METHODS
A cross-sectional study of 1,706 subjects who received their routine health examination was conducted between May 2008 and April 2010 at Konkuk University medical center. Biochemical tests for liver and abdominal ultrasonography were performed. CKD was defined as either proteinuria or glomerular filtration rate < or =60 mL/min per 1.73 m2.
RESULTS
Among the 1,706 subjects, There were 545 (31.9%) with non-alcoholic fatty liver disease and 424 (24.9%) with chronic kidney disease. In univariate logistic regression analysis, NAFLD was significantly associated with CKD (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.34 to 2.12). In multivariate logistic regression analysis adjusted for age, sex, current smoking, abdominal obesity, aspartate aminotransferases, alanine aminotransferases, gamma-glutamyltransferase, hypertension, diabetes mellitus, hypertriglyceridemia, and low high-density lipoprotein cholesterol, NAFLD was associated with CKD (adjusted OR, 1.68; 95% CI, 1.27 to 2.24). This relationship remained significant after classification according to the presence of hypertension or diabetes mellitus.
CONCLUSION
NAFLD diagnosed by ultrasonography was significantly associated with CKD in Koreans aged 50 years or older.

Keyword

Non-alcoholic Fatty Liver Disease; Chronic Renal Insufficiency; Ultrasonography; Glomerular Filtration Rate; Proteinuria

MeSH Terms

Academic Medical Centers
Aged
Alanine
Aspartate Aminotransferases
Cardiovascular Diseases
Cholesterol
Cross-Sectional Studies
Diabetes Mellitus
Fatty Liver
gamma-Glutamyltransferase
Glomerular Filtration Rate
Humans
Hypertension
Hypertriglyceridemia
Lipoproteins
Liver
Logistic Models
Obesity, Abdominal
Proteinuria
Renal Insufficiency, Chronic
Risk Factors
Smoke
Smoking
Transaminases
Alanine
Aspartate Aminotransferases
Cholesterol
Fatty Liver
Lipoproteins
Smoke
Transaminases
gamma-Glutamyltransferase