Korean J Asthma Allergy Clin Immunol.
2008 Mar;28(1):70-73.
A Case of Anaphylaxis due to Repeated Intradermal Testing with Ampicillin
Abstract
- A broad-spectrum aminopenicillin, such as amoxicillin or ampicillin, has been widely used for a variety of infectious diseases. Anaphylaxis to antibiotics is one of the most common fatal IgE-mediated diseases. Skin tests with the culprit beta-lactam antibiotic are common and validated methods for evaluating the presence of IgE antibodies and cross- reactivity between beta-lactam antibiotics in patients with aminopenicilin-induced hypersensitivity. In rare cases, the tests with the culprit drugs can induce anaphylactic reactions; however, it has not yet been elucidated whether repetition of skin testings and time intervals between hypersensitivity and skin testing affect the recurrence of serious anaphylactic reactions. We report herein a case of anaphylactic reaction after repeated skin test with penicillin G, amoxicillin and ampicillin in a 47-year-old man who had shown anaphylaxis to amoxicillin two weaks earlier.
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