Clin Orthop Surg.  2015 Sep;7(3):318-322. 10.4055/cios.2015.7.3.318.

Utilization of Hyaluronate and Incidence of Septic Knee Arthritis in Adults: Results from the Korean National Claim Registry

• Lee YK
• Kim KC
• Ha YC
• Koo KH

• KMID: 2234085
• DOI: http://doi.org/10.4055/cios.2015.7.3.318

Abstract

BACKGROUND
Septic arthritis of the knee has been reported recently in adult patients who were administered hyaluronate. We evaluated the incidence of septic knees and the utilization of hyaluronate in the Korean adult population using nationwide data from the Health Insurance Review and Assessment Service (HIRA).
METHODS
All new admissions to the clinics or hospitals for septic knees were recorded in the HIRA database which was established by the Korean government and covers the Korean population using the International Classification of Diseases-10 revision code. We evaluated the incidence of septic arthritis of the knees in the population above 50 years of age. Hyaluronate prescription data was also collected from the HIRA database.
RESULTS
In 2012, the incidence of septic knees was 2.7 per 100,000 persons in men and 4.2 per 100,000 persons in women, respectively. The age-adjusted incidence of septic knees increased by 6.7% per year (95% confidence interval, 3.3 to 10.1), and the annual number of prescriptions of hyaluronate increased about 1.5-fold during the study period.
CONCLUSIONS
Cautious aseptic technique is required when hyaluronate is administered in adult patients with osteoarthritis of the knee due to the concerns of the risk of septic arthritis.

Keyword

Septic; Arthritis; Hyaluronic acid; Knee

MeSH Terms

Arthritis, Infectious/*epidemiology/etiology
Female
Humans
Hyaluronic Acid/administration & dosage/*therapeutic use
Incidence
Injections, Intra-Articular/*adverse effects/statistics & numerical data
Knee Joint/physiopathology
Male
Middle Aged
Osteoarthritis, Knee/drug therapy
Republic of Korea/epidemiology
Hyaluronic Acid

Figure

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  Fig. 1 The number of septic knees (A) and the age-adjusted incidence of septic knees (B) in the population above 50 years of age from 2008 to 2012.

• 

  Fig. 2 The number of prescriptions of hyaluronate from 2008 to 2012.

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