Korean J Dermatol.  1985 Oct;23(5):620-629.

An Experimental Study on Comedogenicity of Several External Contactants

• Ahn HY
• Myung KB
• Hahm JH
• Kook HI

Abstract

The present study was performed to evaluate the comedogenicity of several cosmetic ingredients, vegetable oils, steroid and sulfur. The test materials were applied to one ear canal of rabbits for 6 weekdays for 2 weeks. The results were as follows: l. Among the 14 cosmetic ingredients, no comedogenicity was shown in propylene glycol and petrolatum, mild comedogencity in squalene, acetylated lanolin, polyethylene glycol, cetyl aIcohol and Tween 80. Propylene glycol, sodium lauryl sulfate and oleic acid showed moderate comedogenicity. Severe comedogenicity was observed in myristyl myristate, isopropyl myristate, butyl stearate and myristyl lactate. 2. Moderate to severe comedogenicity was shown in olive oil, sesame oil and corn oil and moderate comedogenicity in sulfur (8%) and betamethasone dipropionate (0.06%) R. Histopathologic grading were paralleled the findings of the naked eye.

Keyword

Comedogenicity

MeSH Terms

Betamethasone
Corn Oil
Ear Canal
Lactic Acid
Lanolin
Myristic Acid
Olea
Oleic Acid
Petrolatum
Plant Oils
Polyethylene Glycols
Polysorbates
Propylene Glycol
Rabbits
Sesame Oil
Sodium Dodecyl Sulfate
Squalene
Sulfur
Olive Oil
Betamethasone
Corn Oil
Lactic Acid
Lanolin
Myristic Acid
Oleic Acid
Petrolatum
Plant Oils
Polyethylene Glycols
Polysorbates
Propylene Glycol
Sesame Oil
Sodium Dodecyl Sulfate
Squalene
Sulfur