Korean J Dermatol.  1986 Oct;24(5):623-630.

Treatment of Gonorrhea with Antibiotic Combination Regimens - Kanamycin plus Benzyl Penicillin G / Probenecid versus Kanamycin plus Trimethoprim-Sulfamethoxazole

• Whang KU
• Kim JH
• Kim JH

Abstract

From August to November 1985 244 bacteriologically proven male uncomplirated goncicoccal urethritis patients at the VD clinic of Choong-Ku Public Health Center form August to November 1985 were divided into group A and group B according to a random number sheet. In group A, treated with kanamycin 2.Ogm, im plus benzyl penicillin-G 5 mega units, im plus probenecid, 1.Ogm, PO; 112 of 121 patients were followed and 10 patients (8.9%) failed to be recovered. In group B, treated with kanamycin, 2,Ogm, im plus trimethoprim-sulfamethoxazole, 9 tahlets, PO; 112 of l23 patients were followed and 7(6.3%) failed. There is no sign.ificant difference between the two groups (p>0. 05) The failure rates in PPNG urethritis were 14.3% and 8.0% in group A and group B respectively. There is a signficant difference in failure rate between the two groups (P<0.05). It is suggested that, because of high rate of PPNG among circulating N.gonorrhoeae, the combinatioin regimen of kanamycin and trime.thoprim-sulfamethoxazole may be used as a first line treatrnent regimen for uncomplicated gonococcal urethritis.

Keyword

Gonorrheal urethritis; Combination treatment; Trimethoprim - sulfamethoxazole

MeSH Terms

Gonorrhea*
Humans
Kanamycin*
Male
Penicillin G*
Penicillins*
Probenecid*
Public Health
Trimethoprim, Sulfamethoxazole Drug Combination*
Urethritis
Kanamycin
Penicillin G
Penicillins
Probenecid